Risk Factors for Delayed Recurrence of Clostridium difficile Infection
نویسنده
چکیده
associated diarrhea, 27 patients (21.6%) experienced one or more recurrence, and the risk factors for the CDI recurrence were identified as advanced age (over 65 years), a serum albumin level below 2.5 g/dL, and concurrent use of proton pump inhibitors. Jung et al. suggested that a history of surgery is a predictor of recurrence after metronidazole treatment of CDI. In a study by Ryu et al., patients who received tube feeding were at an increased risk of recurrent CDI. However, in these studies, the recurrence of CDI was evaluated only between weeks and 90 days only. In the present study, the authors investigated the longterm clinical outcomes of CDI in hospitalized patients in a single center. The authors evaluated delayed CDI recurrence after eight weeks of successful treatment response. The predictive factors associated with delayed CDI recurrence were tube feeding, and the use of anti-gastric acid medications. Tube feeding is a known risk factor for CDI because it can act as a transmission factor for C. difficile . Aseptic control of the feeding tube may aid in reducing contamination, and therefore preventing CDI. Another important result of this study is the mortality rate of patients with CDI. Although no deaths were attributed to CDI, the results of this study suggest that CDI may predict the poor prognosis of underlying diseases. As the authors mentioned, this study was limited in that it was retrospective, performed in a single center, and the hypervirulent strain was not evaluated appropriately. Another weak point of this study is that antacid medication history was not clearly defined. It would have been better if the authors had clarified the temporal relationship between antRisk Factors for Delayed Recurrence of Clostridium difficile Infection
منابع مشابه
Long-Term Clinical Outcome of Clostridium difficile Infection in Hospitalized Patients: A Single Center Study
BACKGROUND/AIMS Antibiotic usage and increasingly aging populations have led to increased incidence of Clostridium difficile infection (CDI) in worldwide. Recent studies in Korea have also reported increasing CDI incidence; however, there have been no reports on the long-term outcomes of CDI. We therefore investigated the long-term clinical outcomes of patients with CDI, including delayed recur...
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Recurrent Clostridium difficile infection (CDI) is one of the most difficult problems in healthcare infection control. We evaluated the risk factors associated with recurrence in patients with CDI. A retrospective cohort study of 84 patients with CDI from December 2008 through October 2010 was performed at Pusan National University Yangsan Hospital. Recurrence occurred in 13.1% (11/84) of the c...
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BACKGROUND Clostridium difficile infection (CDI) can lead to complications, recurrence, and death. Numerous studies have assessed risk factors for these unfavourable outcomes, but systematic reviews or meta-analyses published so far were limited in scope or in quality. METHODS A systematic review was completed according to PRISMA guidelines. An electronic search in five databases was performe...
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